三維分析腦內(nèi)出血小鼠神經(jīng)元凋亡和血管生成
染色方法：
尼氏染色
標(biāo)記方法：
Nissl染色
包埋方法：
樹脂包埋
成像平臺(tái)：
BioMapping 1000
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figure 2. Representative 3D reconstruction video screenshot of a mouse brain in the vehicle and EGb761 groups, respectively.The regions in the video covered the lesion area (b, d), and the contralateral area (a, c). From the screenshot images, we can find that the microvessel density was higher in the lesions of the EGb761-treated mice, when compared with the vehicle group.
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figure 2. Representative 3D reconstruction video screenshot of a mouse brain in the vehicle and EGb761 groups, respectively.The regions in the video covered the lesion area (b, d), and the contralateral area (a, c). From the screenshot images, we can find that the microvessel density was higher in the lesions of the EGb761-treated mice, when compared with the vehicle group.
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2018年2月5日，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院同濟(jì)醫(yī)院神經(jīng)內(nèi)科唐洲平教授課題組，采用MOST獲取腦出血小鼠神經(jīng)血管網(wǎng)絡(luò)的圖像數(shù)據(jù)集，揭示銀杏葉提取物 EGb761對(duì)實(shí)驗(yàn)性腦出血神經(jīng)元凋亡的保護(hù)作用。文章發(fā)表在《分子神經(jīng)生物學(xué)》雜志上。
參考文獻(xiàn)
參考文獻(xiàn)[1]:Pan C, Liu N, Zhang P, Wu Q, Deng H, Xu F, Lian L, Liang Q, Hu Y, Zhu S, Tang Z. EGb761 Ameliorates Neuronal Apoptosis and Promotes Angiogenesis in Experimental Intracerebral Hemorrhage via RSK1/GSK3β Pathway. Mol Neurobiol. (2017). doi: 10.1007/s12035-016-0363-8.
武漢東湖新技術(shù)開發(fā)區(qū)豹澥街道高科園三路9號(hào)武漢光谷精準(zhǔn)醫(yī)療產(chǎn)業(yè)基地2.1期13棟12層